Key result
Gradual volume expansion increases MAP ~18 mm Hg in peritoneal dialysis patients, correlating with DLF.
Why the study?
A volume-sensitive inhibitor of [Na,K]ATPase, termed digitalis-like factor (DLF), is postulated to participate in hypertension, but its role in volume expansion in renal failure patients was unclear.
Does volume expansion increase digitalis-like factor activity and blood pressure in end-stage renal failure patients on peritoneal dialysis?
Does volume expansion increase digitalis-like factor activity and blood pressure in end-stage renal failure patients on peritoneal dialysis?
p-value: p=<0.05
Volume expansion in peritoneal dialysis patients increases a unique volume-sensitive digitalis-like factor that correlates with increased blood pressure, suggesting a mechanism for volume-dependent hypertension.
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Supports DLF as mediator of volume-dependent hypertension in PD; leaves open whether modulating DLF alters outcomes.
Graves et al. (1993) studied End-stage renal failure. Gradual, sustained volume expansion was evaluated on Changes in body weight, mean arterial pressure, and serum digitalis-like factor (DLF) activity (p=<0.05). Gradual volume expansion in peritoneal dialysis patients significantly increased mean arterial pressure (18.2 ± 6.4 mm Hg, p<0.05) and serum DLF activity, which correlated with blood pressure.
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