Key result
Multiple risk factors, including hypercholesterolemia and baldness, linked to markedly lower life expectancy from CHD and cancer.
Why the study?
Important risk factors for coronary heart disease and their long-term impact on mortality including cancer were not fully characterized over extended follow-up.
Cohort (n=464)
A 22-year follow-up study highlights that multiple risk factors, including high cholesterol and baldness, significantly decrease life expectancy due to both cardiovascular and malignant diseases.
May support multifactorial risk stratification in primary prevention; leaves open causal roles for baldness in cancer mortality.
The Kockum study of risk factors for coronary heart disease (CHD) consists of 464 individuals, one third white collar workers, one third heavy workers and one third well trained firemen, all of whom have now been followed for 22 years. Important risk factors for CHD seem to be heredity, smoking, stress, lack of physical activity, diabetes mellitus hypertension, high body weight, ECG abnormalities, hypercholesterolemia, hypertriglyceridemia and baldness. In addition to the common risk factors, baldness seems to be of importance. A high cholesterol value predisposes for an increased death rate not only due to CHD but also to malignant disease. A Cox analysis shows a markedly decreased life expectancy in multirisk factor patients caused not only by CHD but also by cancer.
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Persson et al. (1984) conducted a cohort in Coronary heart disease (n=464). Multiple risk factors (including high cholesterol and baldness) was evaluated on Life expectancy and death rate due to CHD and cancer. Multiple risk factors, including high cholesterol and baldness, were associated with markedly decreased life expectancy due to both coronary heart disease and cancer over 22 years.
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