Key result
Calcium and calcitriol replacement improves HF symptoms in a patient with severe hypocalcemia-induced takotsubo cardiomyopathy.
Why the study?
The etiology and pathophysiology of takotsubo cardiomyopathy have not yet been fully clarified, particularly in association with severe hypocalcemia secondary to hypoparathyroidism.
Does calcium and calcitriol replacement improve heart failure symptoms in a patient with takotsubo cardiomyopathy associated with severe hypocalcemia secondary to idiopathic hypoparathyroidism?
Case Report (n=1)
Does calcium and calcitriol replacement improve heart failure symptoms in a patient with takotsubo cardiomyopathy associated with severe hypocalcemia secondary to idiopathic hypoparathyroidism?
Severe hypocalcemia secondary to hypoparathyroidism can be a reversible cause of takotsubo cardiomyopathy that responds dramatically to calcium and calcitriol replacement.
Answers are grounded in this paper and cite their sources.
Hypocalcemia correction may improve HF in takotsubo cardiomyopathy; leaves open causal role and applicability beyond this case.
The etiology and pathophysiology of takotsubo cardiomyopathy have not yet been fully clarified. We report a case of takotsubo cardiomyopathy associated with severe hypocalcemia secondary to hypoparathyroidism. A 69-year-old woman presented with acute pulmonary edema caused by severe left ventricular dysfunction with apical ballooning compatible with takotsubo cardiomyopathy. Laboratory tests revealed severe hypocalcemia secondary to idiopathic hypoparathyroidism. Coronary angiography showed normal coronary artery function. Her symptoms and signs of heart failure improved dramatically with the correction of hypocalcemia through calcium and calcitriol replacement.
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Rhee et al. (2013) conducted a case report in Takotsubo cardiomyopathy associated with severe hypocalcemia secondary to idiopathic hypoparathyroidism (n=1). Calcium and calcitriol replacement was evaluated on Improvement of symptoms and signs of heart failure. Calcium and calcitriol replacement dramatically improved symptoms and signs of heart failure in a patient with takotsubo cardiomyopathy secondary to severe hypocalcemia.
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