Key result
Biofeedback linked to a ~49% reduction in migraine disability scores and improved oxidative stress markers.
Why the study?
The role of biofeedback in limiting migraine disability by influencing oxidative stress in chronic migraine patients was investigated.
Does biofeedback improve oxidative stress markers and disability in female patients with chronic migraine?
Observational (n=40)
Does biofeedback improve oxidative stress markers and disability in female patients with chronic migraine?
Absolute Event Rate: 18.8% vs 36.9%
p-value: p=<0.001
Biofeedback may reduce migraine disability by decreasing oxidative stress and improving psychological well-being.
May support biofeedback for chronic migraine disability in women; hypothesis-generating and requires randomized confirmation before practice change.
Chronic migraine (1.5.1) is burdened with headache-related disability. During noxious stimulation, changes of cerebral blood flow enhance the release of oxygen free radicals that react with nitric oxide (NO). We investigated the role of biofeedback in limiting migraine disability by influencing oxidative stress. Peroxides, NO and superoxide dismutase (SOD) were analysed in 20 female subjects with chronic migraine and in 20 female healthy controls before and after biofeedback sessions. NO(x) levels (23.7 +/- 4.2 vs. 34.9 +/- 4.6 microm; P < 0.05) and SOD activity (6.5 +/- 1.0 vs. 8.0 +/- 0.7 U/ml; P < 0.05) were lower in migraine sufferers before treatment than in healthy controls, whereas peroxide levels (145.8 +/- 40.3 vs. 78.0 +/- 20.0 microm; P < 0.05) were higher in migraine sufferers before treatment than in healthy controls. In migraine sufferers NO(x) levels (23.7 +/- 4.2 vs. 31.3 +/- 7.1 microm; P < 0.05) and SOD activity (6.5 +/- 1.0 vs. 7.9 +/- 0.9 U/ml; P < 0.05) were lower before than after treatment, whereas peroxide levels (145.8 +/- 40.3 vs. 82.4 +/- 21.1 microm; P < 0.05) were higher before than after treatment. SOD serum activity correlated positively with NO(x) serum levels and negatively with peroxide serum levels in healthy controls and in chronic migraine sufferers before and after biofeedback. The mean Migraine Disability Assessment Score before biofeedback sessions was higher than after treatment (36.9 +/- 13.9 vs. 18.8 +/- 10.4; P < 0.001). The effectiveness of biofeedback in limiting chronic migraine may be related to muscular relaxation associated with decreased oxidative stress accompanied by psychological well-being.
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Ciancarelli et al. (2007) conducted an observational in Chronic migraine (n=40). Biofeedback vs. Before treatment (baseline) was evaluated on Migraine Disability Assessment Score (p=<0.001). Biofeedback significantly reduced the mean Migraine Disability Assessment Score from 36.9 to 18.8 (P<0.001) and improved oxidative stress markers in female patients with chronic migraine.
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