Electrochemical sensing of uric acid at cerium oxide poly (Congo red) modified carbon paste electrode

Aim: In this work, cerium oxide nanoparticles were synthesized and electrochemically polymerized by treatment with 25 mM Congo red. The developed poly Congo red cerium oxide nanoparticles were used to modified the carbon paste electrode for sensing bioactive molecules, as well as antibacterial and antimalarial drugs. Methods: The cerium oxide nanoparticles (CeO2 NPs) were synthesized using a co-precipitation technique and were subsequently characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS) methods. Results: Experimental parameters including pH, sweep rate and concentration studies were investigated for the determination of uric acid. The Poly (Congo red) Cerium oxide modified carbon paste electrode (PCRCeO2MCPE) was employed for the simultaneous analysis of UA and SFZ. The Poly (Congo red) Cerium oxide modified carbon paste electrode (PCRCeO2MCPE) showed excellent sensitivity and selectivity towards electrochemical examination of UA and exhibits enhanced sensitivity for the electrochemical detection of Uric acid (UA) even in the existence of sulfadiazine (SFZ) using cyclic voltammetry (CV). Conclusion: The established detection limits for UA were found to be 0.478 mM and 1.595 mM of LOD and LOQ respectively. Hence, it is recommended to use PCRCeO2MCPE as a bio-probe for further investigation of bioactive compounds and electroanalytical applications.