Key result
A BMI ≥35 kg/m2 was associated with an 84% increased risk of combined cardiovascular morbidity and all-cause mortality compared to non-obese subjects.
Why the study?
Obesity is a major health problem with a known association to cardiovascular risk factors, but its correlation with overall mortality and cardiovascular events in the general population requires further assessment.
Does severe obesity (BMI ≥ 35 kg/m²) increase the risk of mortality and cardiovascular events in the general population?
Cohort (n=1,248)
Does severe obesity (BMI ≥ 35 kg/m²) increase the risk of mortality and cardiovascular events in the general population?
Severe obesity (BMI ≥ 35 kg/m²) is a significant independent predictor of all-cause mortality and cardiovascular events in the general population over a 10-year follow-up.
Answers are grounded in this paper and cite their sources.
BMI ≥35 kg/m² was associated with higher mortality; leaves open whether thresholds should guide risk stratification in general populations.
BACKGROUND: Obesity represents an important health problem and its association with cardiovascular risk factors is well-known. The aim of this work was to assess the correlation between obesity and mortality (both, all-cause mortality and the combined variable of all-cause mortality plus the appearance of a non-fatal first cardiovascular event) in a general population sample from the south-east of Spain. MATERIALS AND METHODS: This prospective cohort study used stratified and randomized two-stage sampling. Obesity [body mass index (BMI) ≥ 30 kg/m(2)] as a predictive variable of mortality and cardiovascular events was assessed after controlling for age, sex, cardiovascular disease history, high blood pressure, diabetes mellitus, hypercholesterolemia, high-density lipoprotein/triglycerides ratio, total cholesterol and smoking with the Cox regression model. RESULTS: The mean follow-up time of the 1,248 participants was 10.6 years. The incidence of all-cause mortality during this period was 97 deaths for every 10,000 person/years (95% CI: 80-113) and the incidence of all-cause mortality+cardiovascular morbidity was 143 cases for every 10,000 person/years (95% CI: 124-163). A BMI ≥ 35 kg/m(2) yielded a hazard ratio for all-cause mortality of 1.94 (95% CI: 1.11-3.42) in comparison to non-obese subjects (BMI <30 kg/m(2)). For the combination of cardiovascular morbidity plus all-cause mortality, a BMI ≥ 35 kg/m(2) had a hazard ratio of 1.84 (95% CI: 1.15-2.93) compared to non-obese subjects. CONCLUSIONS: A BMI ≥ 35 kg/m(2) is an important predictor of both overall mortality and of the combination of cardiovascular morbidity plus all-cause mortality.
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Ponce-García et al. (2015) conducted a cohort in General population (n=1,248). Obesity (BMI ≥35 kg/m2) vs. Non-obese subjects (BMI <30 kg/m2) was evaluated on Combination of cardiovascular morbidity plus all-cause mortality (HR 1.84, 95% CI 1.15-2.93, p=0.011). A BMI ≥35 kg/m2 was associated with an 84% increased risk of combined cardiovascular morbidity and all-cause mortality compared to non-obese subjects.
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