Key result
Labetalol achieves blood pressure control in ~60% of patients with severe, drug-resistant hypertension.
Why the study?
Labetalol's long-term safety and efficacy in patients with severe hypertension resistant to multiple drugs was not well established.
Does labetalol improve blood pressure control in patients with severe resistant hypertension?
Observational (n=83)
Does labetalol improve blood pressure control in patients with severe resistant hypertension?
Labetalol is effective and safe for achieving blood pressure control in patients with severe hypertension resistant to other drugs.
May support labetalol in thiazide-beta blocker resistant hypertension; leaves open its role versus modern regimens.
Labetalol has been used in 83 patients with severe hypertension resistant to a wide number of drugs. Adequate blood pressure control was achieved in 50 patients. Seven patients with a response in blood pressure had administration of the drug ceased because of side effects. Twenty-two of these resistant patients had little fall in blood pressure. Labetalol can be used safely in severe resistant hypertension and is indicated when a thiazide and beta-blocking drug has failed to reduce blood pressure.
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Myers et al. (1980) conducted an observational in Severe hypertension (n=83). Labetalol was evaluated on Adequate blood pressure control. Labetalol achieved adequate blood pressure control in 60.2% (50 of 83) of patients with severe, drug-resistant hypertension.
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