Key result
Inhibition of the Wnt pathway using FZM1 and iCRT14 reduced viral production by up to tenfold and delayed the onset of cytopathic effect in BVDV-1 infected primary bovine cells.
Population
Madin-Darby Bovine Kidney cells and bovine lung primary cells infected with BVDV-1 cytopathogenic strain
Design
Preclinical
Follow-up
10 and 30 hours post-infection
Authors
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Wnt inhibition merits further BVDV antiviral exploration; leaves open translation beyond primary bovine cells.
p-value: p=<0.05
Inhibition of the Wnt/βcatenin signaling pathway delays the cytopathic effect of BVDV-1 in bovine primary cells, suggesting a potential therapeutic target.
Polla et al. (2022) studied Bovine viral diarrhea virus (BVDV) infection. Wnt pathway inhibitors (iCRT14 and FZM1) vs. Untreated infected cells was evaluated on Viral titer (FAID50/mL) at 24 hours post-infection (p=<0.05). Inhibition of the Wnt pathway using FZM1 and iCRT14 reduced viral production by up to tenfold and delayed the onset of cytopathic effect in BVDV-1 infected primary bovine cells.
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