January 1, 1997Journal of VirologyOpen Access

Authentic and chimeric full-length genomic cDNA clones of bovine viral diarrhea virus that yield infectious transcripts

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Population

Bovine viral diarrhea virus (BVDV) in vitro model

Comparison

Construction of full-length genomic cDNA clones… vs Wild-type parent

Design

Preclinical

Authors

Discussion

Establishes BVDV reverse genetics in vitro; leaves open applications for genomic manipulation and vaccines.

Population

Bovine viral diarrhea virus (BVDV) in vitro model

Intervention

Construction of full-length genomic cDNA clones and chimeric virus (substitution of major envelope glycoprotein E2/gp53)

Comparator

Wild-type parent (National Animal Disease Laboratory strain of BVDV)

Outcome

Production of infectious BVDV and in vitro phenotypesurrogate

The development of a reverse-genetic system for BVDV allows for genomic manipulations and potential development of live vaccine strains.

Vassilev et al. (1997) studied this question.

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