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May 1, 1994Journal of VirologyOpen Access

Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion

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Population

Cytopathogenic bovine viral diarrhea virus (BVDV) isolate CP9 and infected cells

Design

Preclinical

Authors

NTNorbert TautzInstitute for Integrative and Experimental GenomicsHTHeinz‐Jürgen ThielJustus-Liebig-Universität GießenEDEdward J. DuboviUniversity of Arkansas at Little Rock

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Implication

Implicates DI particles in BVDV pathogenesis in cattle; hypothesis-generating and requires validation beyond this animal model.

Structured PICO

P
Population
Cytopathogenic bovine viral diarrhea virus (BVDV) isolate CP9 and infected cells
I
Intervention
Characterization of the CP9 viral genome, cDNA cloning, sequencing, and cell culture expression experiments
O
Outcome
Identification and characterization of the 8-kb BVDV-specific RNA as a defective interfering particle (DI) and its role in cytopathogenicity

The study identifies a cytopathogenic defective interfering particle generated by an internal deletion in BVDV, which is linked to fatal mucosal disease in cattle.

Cite This Study

Tautz et al. (1994) studied this question.

synapsesocial.com/papers/6a7c00461f8f1eb7b8ed4e36https://doi.org/10.1128/jvi.68.5.3289-3297.1994
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Severe clinical disease induced in cattle persistently infected with noncytopathic bovine viral diarrhea virus by superinfection with cytopathic bovine viral diarrhea virus1985 · 259 citations
  2. 2Molecular specificity of the antibody responses of cattle naturally and experimentally infected with cytopathic and noncytopathic bovine viral diarrhea virus biotypes1987 · 70 citations
  3. 3Experimental production of fatal mucosal disease in cattle1984 · 410 citations
  4. 4Characterization of bovine viral diarrhea virus proteins1984 · 70 citations