Population
Bovine viral diarrhea virus (BVDV) replicons and transfected culture cells
Design
Preclinical
Authors
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These replicon pairs enable mechanistic studies of BVDV cytopathogenicity without helpers; leaves open translation to natural bovine infections.
The study establishes the first pair of cytopathogenic and noncytopathogenic BVDV replicons that mimic complete virus phenotypes, demonstrating that helper viruses are not required for host cell lysis.
Tautz et al. (1999) studied this question.
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