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February 1, 1997Journal of VirologyOpen Access

Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs

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Population

Bovine cells and bovine viral diarrhea virus (BVDV) isolate CP7

Comparison

Transfection of RNA transcribed in vitro from a… vs Parental BVDV and noncytopathogenic counterpart…

Design

Preclinical

Authors

GMGregor MeyersFriedrich-Loeffler-InstitutNTNorbert TautzInstitute for Integrative and Experimental GenomicsPBPaul BecherWilmington College

Discussion

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Implication

Recombination drives BVDV cytopathogenicity in vitro; leaves open extension to in vivo pathogenesis or related flaviviruses.

Structured PICO

P
Population
Bovine cells and bovine viral diarrhea virus (BVDV) isolate CP7
I
Intervention
Transfection of RNA transcribed in vitro from a full-length cDNA clone of BVDV isolate CP7
C
Comparator
Parental BVDV and noncytopathogenic counterpart NCP7
O
Outcome
Generation of infectious BVDV and cytopathogenic phenotypesurrogate

Recombination-induced alterations in the genomes of cytopathogenic bovine viral diarrhea viruses are responsible for the induction of cell lysis.

Cite This Study

Meyers et al. (1997) studied this question.

synapsesocial.com/papers/6a702023f44fa9f079ddad66https://doi.org/10.1128/jvi.71.2.1735-1735.1997
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