Population
Bovine viral diarrhea virus (BVDV) strains CP442 and CP552 in cell culture
Design
Preclinical
Authors
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Highlights NS4A/NS4B recombination hotspots in BVDV; leaves open applications for stable heterologous insertions in natural hosts.
The study identifies two genomic loci in pestiviruses suited for the insertion of heterologous sequences, demonstrating that sequence identity influences the mode of RNA recombination.
Gallei et al. (2005) studied this question.
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