May 1, 1998Journal of VirologyOpen Access

Insertion of a Sequence Encoding Light Chain 3 of Microtubule-Associated Proteins 1A and 1B in a Pestivirus Genome: Connection with Virus Cytopathogenicity and Induction of Lethal Disease in Cattle

View Full Paper

Ask AI

Bookmark

Population

Bovine viral diarrhea virus (BVDV) isolates (JaCP and JaNCP) and infectious cDNA clones

Comparison

Insertion of LC3* sequence into the viral genome vs Noncytopathogenic virus without the insertion

Design

Preclinical

Authors

GMGregor MeyersFriedrich-Loeffler-Institut DSDieter StollNatural and Medical Sciences Institute MGMichael D. GunnDuke Medical Center

Discussion

Member takes

Implication

LC3* insertion generates defective or autonomous cp pestiviruses depending on duplication; leaves open relevance to natural pathogenesis or control strategies.

Structured PICO

Population

Bovine viral diarrhea virus (BVDV) isolates (JaCP and JaNCP) and infectious cDNA clones

Intervention

Insertion of LC3* sequence (encoding a fragment of light chain 3 of microtubule-associated proteins 1A and 1B) into the viral genome

Comparator

Noncytopathogenic (noncp) virus without the insertion

Outcome

Virus cytopathogenicity and replication abilitysurrogate

The insertion of a cellular LC3* sequence into the BVDV genome induces additional polyprotein cleavage and is linked to the generation of cytopathogenic pestiviruses.

Cite This Study

Meyers et al. (1998) studied this question.

synapsesocial.com/papers/6a814226ada1eccddc33aace https://doi.org/10.1128/jvi.72.5.4139-4148.1998

View Full Paper

Ask AI

Bookmark

Implication

LC3* insertion generates defective or autonomous cp pestiviruses depending on duplication; leaves open relevance to natural pathogenesis or control strategies.

Insertion of a Sequence Encoding Light Chain 3 of Microtubule-Associated Proteins 1A and 1B in a Pestivirus Genome: Connection with Virus Cytopathogenicity and Induction of Lethal Disease in Cattle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insertion of a Sequence Encoding Light Chain 3 of Microtubule-Associated Proteins 1A and 1B in a Pestivirus Genome: Connection with Virus Cytopathogenicity and Induction of Lethal Disease in Cattle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider