Key result
Antigen challenge in rabbits causes intravascular coagulation driven by immune complex formation.
Why the study?
Intravascular coagulation during immune complex glomerulonephritis and its relation to antigen disposal and fibrinogen catabolism were not fully characterized.
In a rabbit model of immune complex glomerulonephritis, early antigen challenge induces intravascular coagulation and fibrin microthrombi formation, which correlates with precipitating antibody levels and proliferative glomerular changes.
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May link immune complexes to coagulation in experimental models; leaves open relevance to human glomerulonephritis.
E. N. Wardle (1973) studied Immune complex glomerulonephritis. Antigen challenge (bovine serum albumin or horse serum) was evaluated on Intravascular coagulation assessed by catabolism of 131I-fibrinogen and 125I-labelled antigen disposal. Antigen challenge in rabbits caused immune complex formation leading to intravascular coagulation ('rebound defibrination'), which was associated with precipitating antibody and glomerular fibrin microthrombi.
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