Key result
An indwelling intravenous catheter in rabbits significantly increased the absolute catabolic rate of fibrinogen to 112.8 mg/kg/day compared to 58.7 mg/kg/day in normal controls.
Why the study?
Does an indwelling intravenous catheter alter fibrinogen catabolism in rabbits?
Population
Normal rabbits and rabbits with indwelling intravenous catheters, weight between 1.6 and 2.2 kg
Comparison
Siliconized polyvinyl tubing inserted into a… vs Normal rabbits without indwelling catheters
Design
Preclinical
Follow-up
7-9 days
Authors
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Catheter-induced fibrinogen catabolism rise in rabbits does not indicate coagulation activation; leaves open human relevance.
Does an indwelling intravenous catheter alter fibrinogen catabolism in rabbits?
Absolute Event Rate: 112.8% vs 58.7%
Indwelling intravenous catheters in rabbits have minimal effect on intravascular coagulation activation, aside from an increased absolute catabolic rate of fibrinogen.
Mahn et al. (2009) studied Normal rabbits and rabbits with indwelling intravenous catheters. Indwelling intravenous catheter vs. Normal rabbits was evaluated on Absolute catabolic rate of fibrinogen. An indwelling intravenous catheter in rabbits significantly increased the absolute catabolic rate of fibrinogen to 112.8 mg/kg/day compared to 58.7 mg/kg/day in normal controls.