Key result
Human fibrinogen labeled with 125-Iodine using the Iodogen technique showed similar properties to iodine monochloride labeling but with higher labeling efficiency.
Why the study?
Does radiolabeling human fibrinogen with 125-Iodine using Iodogen alter its properties or improve labeling efficiency compared to iodine monochloride?
Population
Human fibrinogen preparations and rabbits (for in vivo clearance studies)
Comparison
Radiolabeling with 125-Iodine using Iodogen as… vs Radiolabeling with iodine monochloride
Design
Preclinical
Authors
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Iodogen offers efficient fibrinogen radiolabeling in animal models; leaves open human diagnostic translation pending further studies.
Does radiolabeling human fibrinogen with 125-Iodine using Iodogen alter its properties or improve labeling efficiency compared to iodine monochloride?
The Iodogen technique provides higher labeling efficiency for human fibrinogen with radioiodine without altering its in vitro or in vivo properties compared to the iodine monochloride method.
Knight et al. (1981) studied this question. Radiolabeling of human fibrinogen with 125-Iodine using Iodogen vs. Iodine monochloride labeled counterpart was evaluated on Thrombin clottability, binding to staphylococci, relative specific radioactivity, and in vivo clearance from plasma in rabbits. Human fibrinogen labeled with 125-Iodine using the Iodogen technique showed similar properties to iodine monochloride labeling but with higher labeling efficiency.
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