Key result
Radioiodinated soluble canine fibrin exhibited faster blood clearance (half-life 5 hours) and higher thrombus-blood ratios in induced venous and coronary artery thrombi compared to labeled fibrinogen.
Why the study?
Does radioiodinated soluble fibrin provide superior thrombus localization compared to labeled fibrinogen in dogs with induced thrombosis?
Population
Dogs with induced venous thrombi, coronary artery thrombi, and myocardial infarction
Comparison
Radioiodinated (131I) soluble canine fibrin vs Radioiodinated fibrinogen
Design
Preclinical
Authors
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May support thrombus imaging agent development; leaves open human translation and clinical validation.
Does radioiodinated soluble fibrin provide superior thrombus localization compared to labeled fibrinogen in dogs with induced thrombosis?
Radioiodinated soluble fibrin demonstrates faster blood clearance and higher thrombus-blood ratios than labeled fibrinogen, suggesting potential advantages as a thrombus detecting agent.
Coleman et al. (1975) studied Thrombosis. Radioiodinated soluble canine fibrin vs. Labeled fibrinogen was evaluated on Thrombus-blood ratio. Radioiodinated soluble canine fibrin exhibited faster blood clearance (half-life 5 hours) and higher thrombus-blood ratios in induced venous and coronary artery thrombi compared to labeled fibrinogen.
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