Why the study?
Can Indium-111-oxine labeled autologous platelets detect thrombi in vivo?
Can Indium-111-oxine labeled autologous platelets detect thrombi in vivo?
Indium-111-labeled platelets can effectively detect newly forming thrombi via scintigraphy, though they are less effective for preformed thrombi.
May support acute thrombus imaging with In-111 platelets; leaves open clinical translation and utility for chronic thrombi.
The use of Indium-111-oxine labeled autologous platelets has been explored in a dog-catheter model, as well as in a variety of clinical disorders in man. Newly forming experimental thrombi in dogs label well during the first 45-90 minutes, then lose both label and thrombus mass in a manner consistent with fibrinolysis. Thrombus weight is linearly related to In-111 activity, so that in vivo scintigraphy will be a practical method to evaluate various thrombotic stimuli and anti-thrombotic interventions experimentally. Preformed thrombus, however, labels poorly and cannot be detected by imaging in this dog model. Initial clinical experience with a variety of arterial, venous and cardiac thrombotic states is reviewed, indicating some of the strengths and same of the potential weaknesses of this new scintigraphic technique.
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Price et al. (1982) studied this question.