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January 1, 2000Angiology

Clinical Assessment of Vascular Thrombosis Using Indium-111 Platelet Scintigraphy

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Key result

Indium-111 platelet scintigraphy correlated with aggravation of acute thrombotic symptoms in deep vein thrombosis and arteriosclerosis obliterans, but was not sensitive for pulmonary embolism.

Why the study?

Does Indium-111 platelet scintigraphy accurately detect thrombotic activity in patients with vascular thrombosis?

Population

77 patients, including 39 with deep vein thrombosis, 28 with arteriosclerosis obliterans, and 10 with…

Design

Cohort

Authors

TSTakaki SugimotoHyogo Prefectural Awaji Medical CenterMOMasayoshi OkadaKurashiki University of Science and the ArtsTMTomoichiroh MukaiChibune General Hospital

Discussion

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Implication

May support indium-111 scintigraphy for DVT and arteriosclerosis obliterans monitoring; leaves open PE role and requires prospective validation.

Study Design

Type

Observational (n=77)

Structured PICO

Does Indium-111 platelet scintigraphy accurately detect thrombotic activity in patients with vascular thrombosis?

P
Population
77 patients with deep vein thrombosis, arteriosclerosis obliterans, or pulmonary embolism evaluated for thrombotic activity using platelet scintigraphy.
E
Exposure
Indium-111 platelet scintigraphy using autologous platelets labeled with indium-111-oxine
O
Outcome
Detection of thrombotic activity at vascular thrombosis sitessurrogate

Indium-111 platelet scintigraphy is useful for assessing thrombotic activity in deep vein thrombosis and arteriosclerosis obliterans, but lacks sensitivity for pulmonary embolism.

Cite This Study

Sugimoto et al. (2000) conducted an observational in Vascular thrombosis (n=77). Indium-111 platelet scintigraphy was evaluated on Correlation of platelet accumulation with acute thrombotic symptoms. Indium-111 platelet scintigraphy correlated with aggravation of acute thrombotic symptoms in deep vein thrombosis and arteriosclerosis obliterans, but was not sensitive for pulmonary embolism.

synapsesocial.com/papers/6a93fc6d189c14fbc5b9469fhttps://doi.org/10.1177/000331970005100110

Topics

Pulmonary embolismDual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets.1980 · 78 citations
  2. 2Effect of aspirin and ticlopidine on platelet deposition in carotid atherosclerosis: assessment by indium-111 platelet scintigraphy.1986 · 16 citations
  3. 3Diagnosis of deep venous thrombosis. A prospective study comparing duplex scanning to contrast venography.1989 · 157 citations
  4. 4Optimal Duration of Oral Anticoagulant Therapy: A Randomized Trial Comparing Four Weeks with Three Months of Warfarin in Patients with Proximal Deep Vein Thrombosis1995 · 359 citations
  5. 5Different Intensities of Oral Anticoagulant Therapy in the Treatment of Proximal-Vein Thrombosis1982 · 731 citations