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May 1, 1980CirculationOpen Access

Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets.

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Why the study?

Does radionuclide scintigraphy with indium-111-labeled autologous platelets accurately detect carotid atherosclerosis compared to contrast angiography in patients with suspected cerebrovascular disease?

Population

34 patients with suspected cerebrovascular disease

Comparison

Radionuclide scintigraphy with indium-111-oxine… vs Contrast angiography (performed in 23 patients)

Design

Cross-sectional

Authors

HDH. H. DavisUniversity of FloridaBSB A SiegelCalifornia Department of Public HealthЛШЛ. А. ШерманNorthwestern University

Discussion

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Implication

May support pathophysiologic assessment of carotid plaques; leaves open diagnostic accuracy versus angiography.

Structured PICO

Does radionuclide scintigraphy with indium-111-labeled autologous platelets accurately detect carotid atherosclerosis compared to contrast angiography in patients with suspected cerebrovascular disease?

P
Population
34 patients with suspected cerebrovascular disease
I
Intervention
Radionuclide scintigraphy with indium-111-oxine labeled autologous platelets
C
Comparator
Contrast angiography (performed in 23 patients)
O
Outcome
Detection of atherosclerotic lesions (accumulation of 111In-platelets at arterial lesions)surrogate

Imaging with 111In-labeled autologous platelets can detect carotid atherosclerotic lesions and may help evaluate their pathophysiologic characteristics.

Cite This Study

Davis et al. (1980) studied this question.

synapsesocial.com/papers/6a84084d84161f555bc51df2https://doi.org/10.1161/01.cir.61.5.982
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Imaging experimental infective endocarditis with indium-111-labeled blood cellular components.1979 · 55 citations
  2. 2Indium‐III: a New Radionuclide Label for Studying Human Platelet Kinetics1979 · 170 citations
  3. 3Joint study of extracranial arterial occlusion. II. Arteriography, techniques, sites, and complications1968 · 541 citations