Why the study?
Does radiolabelled fibrinogen (RLF) injection allow detection of induced venous thrombi in dogs?
Does radiolabelled fibrinogen (RLF) injection allow detection of induced venous thrombi in dogs?
Radiolabelled fibrinogen incorporates into both fresh and pre-existing venous thrombi in a canine model, supporting its potential for detecting human venous thrombosis.
Supports RLF for thrombus detection in dogs; leaves open translation to human venous thrombosis diagnosis.
The time course and locus of radiolabelled fibrinogen (RLF) incorporation into venous thrombi were studied in dogs. Incorporation of radiolabelled fibrinogen (RLF) into fresh venous thrombi induced in vivo was studied by serial autoradiography, well-counting and surface counting. Autoradiographs disclosed diffuse incorporation of RLF into thrombi formed before and after RLF injection. Well-counting data also reflected thrombus RLF accumulation in both instances, although this accumulation was discernible earlier in thrombi induced in the presence of circulating RLF. Thrombi induced prior to RLF injection were detectable by surface counting after six hours. These studies support the potential value of RLF in detecting human venous thrombosis but also point out the limitations of the technique as well as questions which require clarification.
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Kravis et al. (1974) studied this question.
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