Why the study?
Does radioimmunoimaging with a fibrin-specific monoclonal antibody successfully image aged canine deep venous thrombi compared to fresh thrombi?
Does radioimmunoimaging with a fibrin-specific monoclonal antibody successfully image aged canine deep venous thrombi compared to fresh thrombi?
Radioimmunoimaging with a fibrin-specific monoclonal antibody can successfully detect aged venous thrombi in a canine model, with uptake equivalent to fresh thrombi.
Radioimmunoimaging of fresh canine venous thrombi with a murine monoclonal antibody specific for human and dog fibrin has been reported. Successful imaging of canine deep venous thrombi 1, 3, and 5 days old at the time of antibody injection is reported. Images were positive in all dogs, and the uptake of fibrin-specific antibody was equivalent to that of fresh thrombi.
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Rosebrough et al. (1987) studied this question.
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