Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1954Experimental Biology and Medicine

Labeling of Rabbit Platelets with Iodine131

View Full Paper
Ask AI
Bookmark
Share

Population

Rabbit platelets

Design

Preclinical

Authors

MMMichael C. MorganUniversity of Wisconsin–MadisonRKRichard P. KeatingNewYork–Presbyterian HospitalEREdward Hartman ReisnerMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

Loading...

Member takes

Overview

In vitro labeling may injure platelets and preclude metabolic studies; leaves open need for validated in vivo methods.

Structured PICO

P
Population
Rabbit platelets
I
Intervention
In vitro labeling with radioiodine (Iodine131) after separation from plasma proteins
O
Outcome
In vivo survival (disappearance from circulation) and clot retraction promotionsurrogate

In vitro labeling of rabbit platelets with Iodine131 causes injury during separation, making them unsuitable for in vivo metabolism studies.

Limitations

  • Separation of platelets from plasma proteins causes injury, making the method unadaptable to in vivo metabolism studies.

Cite This Study

Morgan et al. (1954) studied this question.

synapsesocial.com/papers/6a709681ac440176ef293f82https://doi.org/10.3181/00379727-85-20902
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subcellular localization of 111In in human and rabbit platelets1982 · 32 citations
  2. 2The influence of the ‘collection injury’ on the survival and distribution of Indium‐ 111 ‐labelled canine platelets1982 · 16 citations
  3. 3Indium‐III: a New Radionuclide Label for Studying Human Platelet Kinetics1979 · 170 citations
  4. 4Radiolabeling of Fibrinogen Using the Iodogen Technique1981 · 61 citations
  5. 5Effect of Repeated Treatment of Rabbit Platelets with Low Concentrations of Thrombin on their Function, Metabolism and Survival1973 · 106 citations