Key result
111In-oxine labeling resulted in 111In concentration within dense bodies in rabbit platelets, whereas human platelets accumulated almost all the radiolabel within the cytosol.
Population
Human and rabbit platelets
Design
Preclinical
Authors
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Rabbit-human differences in 111In localization caution against extrapolating rabbit platelet studies to humans; leaves open optimal radiolabeling for clinical survival and imaging.
The subcellular localization of 111In differs significantly between human and rabbit platelets, with implications for the interpretation of platelet survival and imaging studies.
Baker et al. (1982) studied this question. 111In-oxine labeling vs. Human vs rabbit platelets was evaluated on Subcellular distribution of 111In. 111In-oxine labeling resulted in 111In concentration within dense bodies in rabbit platelets, whereas human platelets accumulated almost all the radiolabel within the cytosol.
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