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January 1, 1979Thrombosis and Haemostasis

Preparation of a Viable Population of Indium-111- Labelled Human Blood Platelets

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Population

Human blood platelets

Design

Preclinical

Authors

AHA.duP. HeynsUniversity of the Free StatePBP N BadenhorstUniversity of the Free StateHPH PietersSouth African Medical Research Council

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Overview

Supports 111In-oxine platelet labeling for kinetic research; leaves open clinical translation pending human in vivo validation.

Structured PICO

P
Population
Human blood platelets
I
Intervention
Labelling with 111Indium-8-hydroxyquinoline ([111In]-oxine) under optimized conditions (saline pH 5.5, 30 min at 22 degrees C, 6.25 mg oxine/litre)
O
Outcome
Labelling efficiency and platelet viability (aggregation, ultrastructure, label retention)surrogate

Human platelets labelled with 111In-oxine under optimized conditions maintain viability and are suitable for in vivo kinetic studies.

Cite This Study

Heyns et al. (1979) studied this question.

synapsesocial.com/papers/6a8ada7cb676b7d1a2fb4085https://doi.org/10.1055/s-0038-1657048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Indium‐III: a New Radionuclide Label for Studying Human Platelet Kinetics1979 · 170 citations
  2. 2Kinetics and Fate of 111Indium-Oxine Labelled Blood Platelets in Asplenic Subjects1980 · 20 citations
  3. 3The influence of the ‘collection injury’ on the survival and distribution of Indium‐ 111 ‐labelled canine platelets1982 · 16 citations
  4. 4Radiolabelling of human platelets with <sup>99m</sup>Tc‐HMPAO1989 · 2 citations
  5. 5Subcellular localization of 111In in human and rabbit platelets1982 · 32 citations