Why the study?
What is the survival and tissue distribution of 111Indium-oxine labelled autologous platelets in asplenic subjects?
Population
4 asplenic subjects
Comparison
111Indium-oxine labelled autologous platelets vs Normal subjects
Design
Case_series
Follow-up
240 hours
Authors
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Platelet kinetics in asplenia warrant cautious clinical use; leaves open validation of liver and marrow clearance in larger studies.
What is the survival and tissue distribution of 111Indium-oxine labelled autologous platelets in asplenic subjects?
This study demonstrates that in the absence of a spleen, senescent platelets are primarily destroyed in the liver and bone marrow, exhibiting a linear survival curve.
Heyns et al. (1980) studied this question.
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