Why the study?
Does biological filtering of Indium-111-labelled platelets alter their survival and distribution in beagle dogs compared to unfiltered platelets?
Population
3 matched pairs of beagle dogs (n=6)
Comparison
'Filtered' Indium-111-labelled canine platelets vs 'Unfiltered' Indium-111-labelled canine platelets
Design
Preclinical
Authors
Loading...
Current In-111 platelet labelling remains suitable in dogs; leaves open minor curve-shape effects for human validation.
Does biological filtering of Indium-111-labelled platelets alter their survival and distribution in beagle dogs compared to unfiltered platelets?
Current isolation and labelling techniques for platelets with In-111-oxine are suitable for quantitative in vivo studies, though survival curve shapes may be slightly influenced by the procedure.
BBADENHORST et al. (1982) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: