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May 1, 1989European Journal Of Haematology

Radiolabelling of human platelets with 99mTc‐HMPAO

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Why the study?

Can 99mTc-HMPAO-labelled autologous platelets be used to image fresh deep vein thrombosis?

Population

5 patients with verified fresh deep vein thrombosis in the lower leg

Design

Case_series

Authors

MVM. VornePäijät-Hämeen KeskussairaalaTHTuomo HonkanenTampere UniversityKKK. KarppinenWihuri Research Institute

Discussion

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Implication

Supports feasibility of 99mTc-HMPAO platelet scintigraphy for untreated DVT; leaves open clinical utility pending controlled trials.

Structured PICO

Can 99mTc-HMPAO-labelled autologous platelets be used to image fresh deep vein thrombosis?

P
Population
5 patients with verified fresh deep vein thrombosis in the lower leg
I
Intervention
Injection of autologous platelets labelled with 99mTc-HMPAO
O
Outcome
Uptake of 99mTc-HMPAO-labelled platelets in scintigraphysurrogate

99mTc-HMPAO-labelled platelets offer a promising imaging tool for evaluating deep vein thrombosis, though heparin therapy may interfere with uptake.

Cite This Study

Vorne et al. (1989) studied this question.

synapsesocial.com/papers/6a707cb0e5469ee92be13602https://doi.org/10.1111/j.1600-0609.1989.tb01475.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism.1980 · 36 citations
  2. 2Diagnosis of deep vein thrombosis using autologous indium-III-labelled platelets.1981 · 54 citations
  3. 3Indium-111 platelet scintigraphy for the diagnosis of acute venous thrombosis.1986 · 49 citations