Key result
UW solution preserves LV function better than Celsior, reducing CK-MB ~65% after 24-hour heart storage.
Why the study?
Improvement of long-term heart preservation methods would potentially increase the donor pool and improve survival, but comparative efficacy of UW and Celsior solutions after 24-h preservation was unclear.
Does the UW solution improve ventricular and endothelial function compared to the Celsior solution in isolated rabbit hearts after 24-h preservation?
Does the UW solution improve ventricular and endothelial function compared to the Celsior solution in isolated rabbit hearts after 24-h preservation?
Absolute Event Rate: 10.7% vs 30.4%
p-value: p=<0.01
The UW solution demonstrated better preservation of left ventricular function and lower myocardial injury markers than the Celsior solution after 24 hours in a rabbit heart model.
UW solution was associated with better LV function than Celsior after 24-h rabbit preservation; leaves open translation to clinical donor hearts.
OBJECTIVE: Improvement of long-term heart preservation methods would potentially increase the donor pool and improve survival. We compared the efficacies of the University of Wisconsin (UW) and Celsior solutions on ventricular and endothelial functions after 24-h preservation. METHODS: We used an isolated heart preparation perfused with blood. The heart was excised from a rabbit, stored for 24 h in the UW or Celsior solution, and then perfused with blood from a support-rabbit. We evaluated cardiac output and coronary endothelial function. RESULTS: The Frank-Starling curve showed a significant left and upward shift in the UW group compared with that in the Celsior group (p<0.01). There were no significant differences between the groups for the coronary blood flow in response to sodium nitroprusside or acetylcholine. The serum creatine kinase MB level after reperfusion was significantly lower in the UW group than in the Celsior group (10.7+/-1.4 ng/mL vs 30.4+/-5.4 ng/mL, p<0.01), whereas lipid peroxide levels did not differ significantly between the two groups. CONCLUSIONS: The UW group showed better left ventricular function than the Celsior group, indicating that the UW solution has greater potential for long-term preservation than Celsior solution.
No takes yet. Share an insight, caveat, or question.
Kajihara et al. (2006) studied Heart preservation. University of Wisconsin (UW) solution vs. Celsior solution was evaluated on Serum creatine kinase MB level after reperfusion (p=<0.01). The University of Wisconsin solution yielded better left ventricular function and lower serum creatine kinase MB levels (10.7 vs 30.4 ng/mL, p<0.01) than Celsior after 24-hour heart preservation.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: