Key result
Higher SBP is linked to ~15% greater stroke risk per 10 mm Hg, outpredicting DBP after age 46.
Why the study?
Age-related shifts in the relative importance of systolic and diastolic blood pressures as predictors of stroke and their interaction with other cardiovascular risk factors were unclear.
Population
68,551 subjects aged 19 to 78 years without cardiovascular disease or antihypertensive treatment from 34 European cohorts
Comparison
Systolic blood pressure vs diastolic blood pressure at different age ranges
Design
Multicohort observational study with multivariate-adjusted Cox regression analysis
Follow-up
Mean 13.2 years
Authors
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Age-stratified BP assessment may refine stroke risk estimation in Europeans; leaves open whether thresholds or treatment should change.
Cohort (n=68,551)
Yes
Hazard Ratio: 1.15 (95% CI 1.12–1.18)
In European cohorts, both SBP and DBP predict stroke risk until age 62, but SBP becomes the superior predictor after age 46, while very low DBP (<71 mm Hg) is inversely associated with stroke risk starting at age 50.
Vishram et al. (2012) conducted a cohort in Stroke (n=68,551). Systolic and diastolic blood pressure was evaluated on Stroke incidence (HR 1.15, 95% CI 1.12-1.18). Higher systolic blood pressure (HR 1.15; 95% CI 1.12-1.18 per 10-mm Hg increase) and diastolic blood pressure ≥71 mm Hg increased stroke risk, with SBP being a superior predictor after age 46.
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