Key result
Combined Yacoub VSARR and intracardiac repair preserves native aortic valve function in unoperated adult TOF.
Why the study?
Experience with valve-sparing aortic root replacement in unoperated adult tetralogy of Fallot patients is exceptionally limited despite progressive aortic root dilation being life-threatening.
Case Report (n=1)
This case demonstrates the feasibility of combining Yacoub valve-sparing aortic root replacement with primary intracardiac tetralogy of Fallot repair in unoperated adults, preserving native aortic valve function while correcting congenital anatomy.
VSARR may be feasible in unoperated adult TOF with aortic dilation; leaves open durability, safety, and applicability pending larger series.
Background: Progressive aortic root dilation represents a life-threatening sequela of uncorrected tetralogy of Fallot (TOF), predisposing patients to aortic regurgitation, dissection, and rupture. Valve-sparing aortic root replacement (VSARR) offers an attractive alternative to mechanical valve replacement by eliminating prosthesis-related complications and lifelong anticoagulation. However, experience with VSARR in unoperated adult TOF patients remains exceptionally limited. Case presentation: We report a 35-year-old male with unrepaired TOF who presented with progressive exertional dyspnea, cyanosis, and atrial fibrillation. Comprehensive imaging revealed severe aortic root dilation (55.4 mm), moderate-to-severe aortic regurgitation, perimembranous ventricular septal defect, infundibular stenosis, and secundum atrial septal defect. We performed single-stage surgical correction comprising ventricular septal defect closure, infundibular resection, pulmonary valvotomy with transannular patch, atrial septal defect closure with fenestration, and Yacoub remodeling VSARR. The patient tolerated the 208-min cardiopulmonary bypass procedure well, with immediate postoperative echocardiography demonstrating trivial aortic regurgitation. He was discharged on postoperative day 7 in sinus rhythm without complications. Conclusions: This case demonstrates the feasibility of combining Yacoub VSARR with primary intracardiac TOF repair in unoperated adults. The procedure successfully preserved native aortic valve function while correcting congenital anatomy, avoiding prosthetic valve-related morbidity. This approach may expand surgical options for adults with TOF-associated aortopathy, though long-term durability data are needed.
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Feng et al. (2026) conducted a case report in Unrepaired tetralogy of Fallot with severe aortic root dilation (n=1). Combined Yacoub valve-sparing aortic root replacement and primary intracardiac TOF repair was evaluated on Postoperative aortic regurgitation and surgical feasibility. Combined Yacoub valve-sparing aortic root replacement and primary intracardiac repair successfully preserved native aortic valve function with trivial regurgitation in an unoperated adult with TOF.
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