Key result
Lorcainide inhibits myocardial Na+, K+-ATPase activity with an IC50 of ~34 microM and potentiates ouabain.
Why the study?
The effects of lorcainide on myocardial Na+, K+-ATPase activity and its comparison with ouabain were investigated to understand its inhibitory potential.
Does lorcainide inhibit microsomal Na+, K+-ATPase activity in guinea-pig isolated heart preparations?
Population
Guinea-pig isolated heart microsomal Na+, K+-ATPase preparations
Comparison
Lorcainide (0.15-125 microM) vs ouabain (0.05-100 microM)
Design
Preclinical experimental study
Authors
Loading...
Lorcainide inhibits myocardial Na+,K+-ATPase in vitro; leaves open relevance to clinical effects or toxicity.
Does lorcainide inhibit microsomal Na+, K+-ATPase activity in guinea-pig isolated heart preparations?
Absolute Event Rate: 33.5% vs 2.1%
Lorcainide acts as a potent inhibitor of myocardial Na+, K+-ATPase and potentiates the inhibitory effects of ouabain in guinea-pig heart preparations.
Almotrefi et al. (1991) studied this question. Lorcainide vs. Ouabain was evaluated on Inhibition of microsomal Na+, K(+)-ATPase activity (IC50). Lorcainide inhibited myocardial Na+, K+-ATPase activity in a concentration-dependent manner with an IC50 of 33.5 microM, and potentiated the inhibitory effects of ouabain.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: