Key result
Class I antiarrhythmic drugs appear to preferentially bind closed cardiac sodium channels to prevent sodium influx.
Why the study?
Despite widespread use of Class I antiarrhythmic drugs, understanding of their mechanism of action on cardiac sodium channels remains incomplete.
Population
Rat cardiac myocyte sodium channels
Comparison
Class I antiarrhythmic drugs binding vs no binding
Design
Review
Authors
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May refine in vitro sodium channel models; leaves open clinical translation for Class I antiarrhythmics.
Describes the mechanistic model of Class I antiarrhythmic drugs binding preferentially to the closed state of cardiac sodium channels.
Sheldon et al. (1989) reported a review. Class I antiarrhythmic drugs was evaluated. Class I antiarrhythmic drugs appear to bind preferentially to a closed state of the cardiac sodium channel, preventing channel opening and subsequent sodium influx.
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