Key result
Frequent premature ventricular contractions (>25% per day) led to rapid cardiomyopathy in one patient, whereas another patient with 40-73% PVCs per day had no structural heart changes over 28 years.
Why the study?
The relationship between the number of idiopathic premature ventricular contractions and development of cardiomyopathy with long-term outcomes remains unclear.
Case Report (n=2)
The development of PVC-induced cardiomyopathy is highly variable and not strictly dependent on PVC burden.
Answers are grounded in this paper and cite their sources.
PVC burden alone does not predict cardiomyopathy risk; case reports leave open the role of individual susceptibility factors.
We report a case of two patients with frequent idiopathic premature ventricular contractions. One of them had more than 25% of ventricular contractions per day leading to fast development of cardiomyopathy and its complete regression upon ventricular arrhythmia elimination. The second one had from 40% to 73% of ventricular contractions per day including non-sustained and sustained ventricular tachycardia without any structural changes of the heart during 28 years of follow-up.
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Shubik et al. (2023) conducted a case report in Frequent idiopathic premature ventricular contractions (n=2). Frequent idiopathic premature ventricular contractions was evaluated. Frequent premature ventricular contractions (>25% per day) led to rapid cardiomyopathy in one patient, whereas another patient with 40-73% PVCs per day had no structural heart changes over 28 years.
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