Key result
Diet-induced weight loss is linked to greater QTc shortening in obese women with waist-to-hip ratios >0.85.
Why the study?
The relationship between plasma free fatty acids and QT intervals in obese women with visceral adiposity and the effects of sustained weight loss were not well characterized.
Does diet-induced weight loss over 1 year improve QTc intervals and FFA levels in obese women with visceral adiposity?
Cohort (n=91)
Does diet-induced weight loss over 1 year improve QTc intervals and FFA levels in obese women with visceral adiposity?
Sustained weight loss over 1 year in obese women with abdominal adiposity significantly shortens the QTc interval, which correlates with reductions in plasma free fatty acid levels.
High WHR associates with longer QTc via FFA/catecholamines in obese women; hypothesis-generating for arrhythmia risk stratification.
We evaluated 66 obese patients grouped by waist-to-hip ratio (WHR) into group A (WHR > 0.85, n = 30) and group B (WHR ≤ 0.85, n = 36), before and after 1 yr of diet-induced weight loss compared with 25 nonobese women. Before diet, the longest values of QT intervals and the highest levels of FFA and catecholamines were in group A (P < 0.01). In obese women (both groups), the corrected QT (QTc); interval correlated with plasma FFA (P < 0.01) and catecholamine (P < 0.02) concentrations. After 1 yr of diet, at the same levels of body weight reduction, the decrement of the QTc interval (P < 0.02), FFA (P < 0.01) and catecholamine (P < 0.02) levels were significantly greater in-group A than group B. In multivariate analysis, the decline of the QTc interval after weight loss was associated with changes in plasma FFA independently of changes in WHR and plasma catecholamines. Our data suggest that the QTc interval is tightly correlated with plasma FFA levels; shortening of cardiac repolarization times in the course of long-lasting weight reduction may reduce the risk of ventricular electrical instability, especially in women with abdominal adiposity.
No takes yet. Share an insight, caveat, or question.
Graziamaria Corbi (2002) conducted a cohort in Obesity with visceral adiposity (n=91). Diet-induced weight loss vs. Obese women with WHR ≤ 0.85 (Group B) was evaluated on Decrement of the QTc interval (p=<0.02). Diet-induced weight loss over 1 year led to a significantly greater decrement in the QTc interval among obese women with a waist-to-hip ratio >0.85 compared to those with a ratio ≤0.85 (P<0.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: