Key result
Diet-induced weight loss over 1 year led to a significantly greater decrement in the QTc interval in obese women with abdominal adiposity compared to those without (P < 0.02).
Why the study?
Does diet-induced weight loss over 1 year improve QTc intervals and FFA levels in obese women with visceral adiposity?
Population
91 women, comprising 66 obese patients and 25 nonobese women.
Comparison
Diet-induced weight loss over 1 year vs Baseline values before diet and nonobese women
Design
Cohort
Follow-up
1 year
Authors
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May shorten QTc more in abdominal adiposity; hypothesis-generating for arrhythmia risk reduction, needs randomized confirmation.
Cohort (n=91)
Does diet-induced weight loss over 1 year improve QTc intervals and FFA levels in obese women with visceral adiposity?
p-value: p=<0.02
Sustained weight loss over 1 year significantly shortens the QTc interval in obese women with abdominal adiposity, a change that correlates with reductions in plasma free fatty acids and may reduce the risk of ventricular arrhythmias.
Corbi et al. (2002) conducted a cohort in Obesity (n=91). Diet-induced weight loss vs. Obese women with WHR <= 0.85 (Group B) was evaluated on Decrement of the QTc interval (p=<0.02). Diet-induced weight loss over 1 year led to a significantly greater decrement in the QTc interval in obese women with abdominal adiposity compared to those without (P < 0.02).
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