Key result
Weight reduction using a very-low-calorie diet in obese patients significantly shortened the maximum QTc interval from 445 msec to 434 msec (P<0.05), without significantly changing QTc dispersion.
Why the study?
Does weight reduction via a very-low-calorie diet improve prolonged QTc intervals and QTc dispersion in patients with simple obesity?
Population
72 participants, comprising 36 patients with simple obesity and 36 age- and gender-matched control patients.
Comparison
Behavioral therapy combined with a… vs Age- and gender-matched non-obese control…
Design
Cohort
Authors
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VLCD weight loss may shorten QTc in obesity; hypothesis-generating and should not change practice without RCTs.
Case-Control (n=72)
No
Does weight reduction via a very-low-calorie diet improve prolonged QTc intervals and QTc dispersion in patients with simple obesity?
Absolute Event Rate: 434% vs 445%
p-value: p=<0.05
Weight reduction through a very-low-calorie diet can partially reverse the prolongation of QTc intervals associated with obesity, potentially reducing arrhythmogenic risk.
Mshui et al. (1999) conducted a case-control in Simple Obesity (n=72). Behavioral therapy and very-low-calorie diet vs. Pre-treatment baseline was evaluated on Maximum QTc interval (p=<0.05). Weight reduction using a very-low-calorie diet in obese patients significantly shortened the maximum QTc interval from 445 msec to 434 msec (P<0.05), without significantly changing QTc dispersion.
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