Why the study?
Prolonged QTc has been reported in arterial hypertension and obesity, prompting evaluation of the effects of hypertension and obesity on QTc.
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Obesity, particularly abdominal obesity as measured by waist circumference and waist-hip ratio, is a stronger predictor of QTc prolongation than hypertension in male subjects.
Background QTc (corrected QT interval) is an index of physiological variability of ventricular repolarization. Prolonged QTc has been reported in cardiac failure, arterial hypertension, ischaemic heart disease and in obesity. Aims and Objectives This study was aimed at evaluating the effect of hypertension and obesity on QTc. The objective of the study was to compare the QTc in obese, non-obese hypertensive and normotensive obese male subjects. Method We compared the QTc in obese-hypertensives (n=15), in nonobese hypertensives (n=15) and in obese-normotensives (n=15), comparable for age and sex. Blood pressure was measured in supine position by mercury sphygmomanometer. Body mass index (BMI), WC (waist circumference) and WHR (waist hip ratio) of all patients were calculated. Results QTc was longer in obese hypertensives and obese normotensives compared to nonobese hypertensives(p<0.00). WC and WHR had positive correlation with QTc prolongation in obese hypertensives and obese normotensives. Conclusion This study indicates that obesity is an important predictor of QTc prolongation than blood pressure. Waist circumference and WHR which reflects abdominal obesity have greater association with QTc prolongation.
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Ashok V Divya R (2019) studied this question.
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