Key result
Surgical excision yields up to ~30-month survival in hepatoma with cardiac metastasis.
Why the study?
Hepatocellular carcinoma with cardiac metastasis is a rare advanced cancer with limited clinical and pathologic data to guide treatment.
Does surgical excision improve outcomes in patients with hepatoma and cardiac metastasis?
Observational (n=8)
Does surgical excision improve outcomes in patients with hepatoma and cardiac metastasis?
Surgical excision of cardiac metastasis from hepatoma may provide variable survival benefits ranging from 1 to >30 months.
Small retrospective HCC cardiac metastasis series should not alter practice; leaves open need for prospective data on management.
AIM: To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis. METHODS: Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters were analyzed. RESULTS: Of those eight patients, two (25%) were women and six (75%) were men, with the mean age of 50 years (range, 40-70 years). The presentations included: asymptomatic (75%), heart failure (25%), and pulmonary embolism (12.5%). All lesions involved the right atrium, and extended to the lung (12.5%), inferior vena cava (25%), and left atrium (12.5%). The level of tumor marker, alpha-fetal protein, was not correlated with the severity of metastasis or disease prognosis. Moreover, the availably estimated doubling time was less than 3 mo. The pathological findings included variable hemorrhage and necrosis. The survival time following surgery also varied from one month to more than 30 mo. CONCLUSION: Hepatoma metastasis to the heart was detected in all eight patients. This study demonstrates that surgery might help the outcome in such cases.
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Yu‐Sheng Lin (2007) conducted an observational in Hepatocellular carcinoma with cardiac metastasis (n=8). Surgical excision was evaluated on Survival time following surgery. Surgical excision for hepatoma with cardiac metastasis yielded survival times ranging from one month to more than 30 months in a retrospective cohort of 8 patients.
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