Key result
Genetically determined COVID-19 shows no causal association with atrial fibrillation risk.
Why the study?
The causal association between COVID-19 infection or its severity and susceptibility to atrial fibrillation remains unknown.
Does genetically predicted COVID-19 increase the risk of atrial fibrillation?
Observational
Does genetically predicted COVID-19 increase the risk of atrial fibrillation?
Odds Ratio: 1.111 (95% CI 0.971–1.272)
p-value: p=0.127
This Mendelian randomization study found no clear evidence of a causal relationship between COVID-19 infection or severity and the risk of atrial fibrillation.
Null genetic finding supports no change in post-COVID AF risk assessment; leaves open acute infection or non-genetic effects for prospective study.
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Zhang et al. (2021) conducted an observational in COVID-19 and atrial fibrillation. Genetically determined COVID-19 vs. General population was evaluated on Risk of atrial fibrillation (OR 1.111, 95% CI 0.971-1.272, p=0.127). Genetically determined COVID-19 was not causally associated with the risk of atrial fibrillation (OR 1.111; 95% CI 0.971-1.272; P=0.127).
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