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January 12, 2024Open Access

Metabolic syndrome and mental disorders, particularly depression, share underlying pathophysiological mechanisms such as HPA axis dysfunction and sympathetic nervous system dysregulation.

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Population

Individuals with metabolic syndrome and mental disorders, particularly depression

Design

Review

Key result

Metabolic syndrome and mental disorders, particularly depression, share underlying pathophysiological mechanisms such as HPA axis dysfunction and sympathetic nervous system dysregulation.

Authors

TBTayyeba Idrees ButtKSKiran ShazdiFAFarheen Anjum

Discussion

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Member takes

Overview

May inform integrated assessment of metabolic syndrome and depression; leaves open causal pathways for prospective validation.

Structured PICO

P
Population
Individuals with metabolic syndrome and mental disorders, particularly depression

This review highlights the shared pathophysiological mechanisms between metabolic syndrome and mental disorders like depression, emphasizing the need for integrated care approaches.

Limitations

  • Self-reported data collection instruments for lifestyle factors may introduce bias.

Cite This Study

Butt et al. (2024) conducted a review in Metabolic syndrome and mental disorders. Metabolic syndrome and mental disorders, particularly depression, share underlying pathophysiological mechanisms such as HPA axis dysfunction and sympathetic nervous system dysregulation.

synapsesocial.com/papers/6ab21905b7dabd9fbd87be25https://doi.org/10.53555/jptcp.v31i1.4019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Psychiatric‐Metabolic Interface: Exploring the Interplay Between Mental Disorders and Metabolic Syndrome2026 · 4 citations
  2. 2Biochemical and Metabolic Changes Associated with Depression: A Systematic Review2025
  3. 3Metabolic Dysfunction in Psychiatric Disorders: A Narrative Review of Shared Pathways Between Mental Illness and Cardiometabolic Disease2026
  4. 4Metabolic syndrome and major depression2013 · 217 citations
  5. 5Depression and Metabolic Syndrome: Two Sides of the Same Coin2019 · 2 citations