Key result
Preclinical evidence links stress-induced brain signaling dysregulation to escalated alcohol drinking and relapse.
Why the study?
The interactions between biological stress systems and alcohol drinking and their implications for medication development in alcohol use disorder and stress-related disorders were not fully understood.
Biological stress systems, including the HPA axis and various neuropeptides, represent potential therapeutic targets for alcohol use disorder.
Does not support changing alcohol use disorder management; leaves open translation of stress targets to human trials.
In this review, the effects of stress on alcohol drinking are discussed. The interactions between biological stress systems and alcohol drinking are examined, with a focus on the hypothalamic pituitary adrenal axis, corticotropin releasing factor, dynorphin, neuropeptide Y, and norepinephrine systems. Findings from animal models suggest that these biological stress systems may be useful targets for medications development for alcohol use disorder and co-occurring stress-related disorders in humans.
No takes yet. Share an insight, caveat, or question.
Marcus M. Weera (2019) conducted a review in Alcohol use disorder and stress-related disorders. Stress was evaluated. Preclinical evidence indicates that stress dysregulates brain stress signaling systems, contributing to escalated alcohol drinking and relapse, highlighting these systems as potential therapeutic targets.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: