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September 1, 1998Journal of Surgical Oncology

Surgical resection of isolated adrenal metastases from lung cancer yielded a median survival of 14 to 24 months across pooled studies, suggesting a modest survival advantage.

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Why the study?

Does surgical resection of the adrenal gland improve survival in patients with isolated adrenal metastases from lung cancer?

Population

60 patients with isolated adrenal metastases from lung cancer (pooled from 11 articles)

Comparison

Surgical resection of the adrenal gland vs Nonoperative therapy

Design

Review

Key result

Surgical resection of isolated adrenal metastases from lung cancer yielded a median survival of 14 to 24 months across pooled studies, suggesting a modest survival advantage.

Authors

ABAlan L. BeitlerJUJohn D. UrschelSVSatish Velagapudi

Discussion

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Member takes

Overview

May support adrenalectomy in select patients with isolated metastases; leaves open the need for prospective validation.

Structured PICO

Does surgical resection of the adrenal gland improve survival in patients with isolated adrenal metastases from lung cancer?

P
Population
60 patients with adrenal metastases from lung cancer who underwent surgical resection, pooled from 11 published articles.
I
Intervention
Surgical resection of the adrenal gland (adrenalectomy)
C
Comparator
Nonoperative therapy
O
Outcome
Survival (median survival and 5-year survival)hard clinical

Surgical resection of isolated adrenal metastases from lung cancer may offer a modest survival advantage and occasional long-term survival, though results may be influenced by selection and publication biases.

Limitations

  • Careful patient selection for this aggressive therapy
  • Publication bias in favor of positive treatment outcomes
  • Careful patient selection for aggressive therapy

Cite This Study

Beitler et al. (1998) conducted a review in Adrenal metastases from lung cancer (n=60). Surgical resection of adrenal metastases vs. Nonoperative therapy was evaluated on Median survival. Surgical resection of isolated adrenal metastases from lung cancer yielded a median survival of 14 to 24 months across pooled studies, suggesting a modest survival advantage.

synapsesocial.com/papers/6ab21c9df8eeea9254ff4663https://doi.org/10.1002/(sici)1096-9098(199809)69:1<54::aid-jso11>3.0.co;2-n
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adrenalectomy For Isolated Metastasis In Five Patients With Lung Cancer: Single Centre Experience and Review of the Literature2011 · 2 citations
  2. 2Pooled analysis for surgical treatment for isolated adrenal metastasis and non-small cell lung cancer2016 · 51 citations
  3. 3Pulmonary metastases from adrenal cortical carcinoma: Results of resection1993 · 22 citations
  4. 4Adrenal Oligometastases Secondary to Non-small Cell Lung Cancer—What is the Optimal Treatment Approach?2017 · 5 citations
  5. 5A Case of Spontaneous Regression of Primary Tumor after Adrenalectomy for Primary Lung Cancer with Synchronous Adrenal Metastasis2025