Key result
Glucose-lowering therapies partially correct hypertriglyceridemia and low HDL caused by altered lipoprotein lipase activity.
Why the study?
Many lipoprotein abnormalities occur in untreated hyperglycemic diabetic patients, but the detailed pathophysiology and effects of treatment on hyperlipidemia in diabetes mellitus require clarification.
How does diabetes mellitus and its treatment affect lipoprotein metabolism and hyperlipidemia?
Population
Patients with non-insulin-dependent and insulin-dependent diabetes mellitus
Comparison
Untreated hyperglycemic state vs diabetes treatment with oral sulfonylureas or insulin
Design
Review
Authors
Loading...
Lipid patterns in untreated diabetes merit attention; leaves open their prognostic weight and response to contemporary therapies.
How does diabetes mellitus and its treatment affect lipoprotein metabolism and hyperlipidemia?
This review highlights that glycemic control in diabetes significantly improves but may not completely normalize the atherogenic lipid profile, particularly in type 2 diabetes.
Abbate et al. (1990) conducted a review in Diabetes Mellitus and Hyperlipidemia. Diabetes Mellitus was evaluated. Untreated diabetes mellitus causes hypertriglyceridemia and decreased HDL cholesterol due to altered lipoprotein lipase activity, which partially corrects with glucose-lowering therapies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: