Key result
Worsening RV dysfunction by GLS is linked to a ~70% lower probability of extubation.
Why the study?
The trajectory and clinical importance of right ventricular systolic function and pulmonary hypertension during pediatric acute respiratory distress syndrome are unknown.
Is new or persistent right ventricular systolic dysfunction associated with worse outcomes in children with pediatric acute respiratory distress syndrome?
Cohort (n=74)
No
Is new or persistent right ventricular systolic dysfunction associated with worse outcomes in children with pediatric acute respiratory distress syndrome?
Hazard Ratio: 0.3 (95% CI 0.14–0.67)
p-value: p=0.003
New or persistent right ventricular systolic dysfunction over the first week following pediatric acute respiratory distress syndrome onset is associated with decreased probability of extubation and higher PICU mortality.
May delay extubation in pediatric ICU patients with worsening RV strain; hypothesis-generating pending prospective validation.
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Himebauch et al. (2019) conducted a cohort in pediatric acute respiratory distress syndrome (n=74). New or persistent right ventricular systolic dysfunction vs. No new or persistent right ventricular systolic dysfunction was evaluated on Probability of extubation (subdistribution HR 0.30, 95% CI 0.14-0.67, p=0.003). Worsening right ventricular dysfunction defined by global longitudinal strain was associated with a decreased probability of extubation (subdistribution HR 0.30; 95% CI 0.14-0.67; p=0.003).
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