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January 31, 2015BMB ReportsOpen Access

Physiological functions of the TRPM4 channels via protein interactions

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Authors

CCChang-Hoon ChoYLYoungsun LeeEKEunju Kim

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Overview

Review uncovers trafficking mechanisms and protein interactions of TRPM4 channels in mammalian tissues, highlighting their potential as therapeutic targets in diverse diseases.

Key Points

  • To review the regulatory mechanisms, membrane trafficking processes, and physiological functions of TRPM4 channels driven by protein-protein interactions.
  • Synthesized recent molecular and electrophysiological literature examining TRPM4 channel regulation in mammalian systems.
  • Evaluated reported mechanisms governing TRPM4 plasma membrane delivery, recycling, and heteromeric complex assembly.
  • TRPM4 acts as a calcium-activated, calcium-impermeable cation channel broadly expressed in mammalian tissues, including the brain.
  • Trafficking to the plasma membrane and assembly into heteromeric complexes are critically governed by physical interactions with partner proteins.
  • Perturbations in TRPM4-protein interactions drive pathological states across multiple organ systems, positioning these complexes as actionable drug targets.

Cite This Study

Cho et al. (2015) studied this question.

synapsesocial.com/papers/6ab222630dbea774e0adcd98https://doi.org/10.5483/bmbrep.2015.48.1.252
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Also Consider

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