Key result
Chronic hypoxia reduces resting cardiac PCr/ATP ~12% prior to ventricular dysfunction in rats.
Why the study?
Energetics alteration plays a crucial role in myocardial injury in chronic hypoxia diseases, and 31P MRS can investigate cardiac energetics alterations in vivo.
31P MRS can non-invasively detect early cardiac energetics alterations in a chronic hypoxia rat model prior to the onset of right ventricular dysfunction.
Answers are grounded in this paper and cite their sources.
May signal early hypoxic cardiac stress; hypothesis-generating for human energetics monitoring before dysfunction.
BACKGROUND: Energetics alteration plays a crucial role in the myocardial injury process in chronic hypoxia diseases (CHD). 31P magnetic resonance spectroscopy (MRS) can investigate alterations in cardiac energetics in vivo. OBJECTIVE: To characterize the potential value of 31P MRS in evaluating cardiac energetics alteration of chronic hypoxic rats (CHRs). METHODS: Twenty-four CHRs were induced by SU5416 combined with hypoxia and divided into four groups according to the modeling time of one, two, three and five weeks, respectively. Control group also contains six rats. 31P MRS was performed weekly and the ratio of concentrations of phosphocreatine (PCr) to adenosine triphosphate (ATP) (PCr/ATP) was obtained. In addition, the cardiac structure index and systolic function parameters, including the right ventricular ejection fraction (RVEF), right ventricular end-diastolic volume index (RVEDVi), right ventricular end-systolic volume index (RVESVi), and the left ventricular function parameters, were measured. RESULTS: Decreased resting cardiac PCr/ATP ratio in CHRs was observed at the first week, compared to the control group (2.90±0.35 vs. 3.31±0.45, p = 0.045), while the RVEF, RVEDVi, and RVESVi decreased at the second week (p < 0.05). The PCr/ATP ratio displayed a significant correlation with RVEF (r = 0.605, p = 0.001), RVEDVi, and RVESVi (r = -0.661, r = -0.703; p < 0.001). CONCLUSIONS: 31P MRS can easily detect the cardiac energetics alteration in a CHR model before the onset of ventricular dysfunction. The decreased PCr/ATP ratio likely reveales myocardial injury and cardiac dysfunction.
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A 2021 study studied Chronic hypoxia diseases (n=30). SU5416 combined with hypoxia vs. Control group was evaluated on Resting cardiac PCr/ATP ratio at the first week (p=0.045). Chronic hypoxic rats exhibited a decreased resting cardiac PCr/ATP ratio at the first week compared to controls, preceding the onset of ventricular dysfunction.
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