Key result
Type 2 diabetes linked to ~11% higher serum E-selectin in ischemic heart disease.
Why the study?
The study aimed to determine serum E-selectin concentration as a marker of endothelial dysfunction in ischemic heart disease patients with and without type 2 diabetes mellitus.
Does the presence of type 2 diabetes mellitus worsen markers of endothelial dysfunction in patients with ischemic heart disease?
Cross-Sectional (n=60)
Does the presence of type 2 diabetes mellitus worsen markers of endothelial dysfunction in patients with ischemic heart disease?
Absolute Event Rate: 35.2% vs 31.7%
p-value: p=0.028
Patients with ischemic heart disease and concomitant type 2 diabetes exhibit more pronounced signs of endothelial dysfunction, including elevated E-selectin and reduced capillary density, compared to those without diabetes.
May inform endothelial assessment in IHD with DM; leaves open whether E-selectin improves risk prediction or guides therapy.
Aim To determine concentration of the endothelial dysfunction (ED) marker, serum E-selectine, in patients with ischemic heart disease (IHD) in combination with type 2 diabetes mellitus (DM) and without DM.Material and methods The study included 60 IHD patients; 31 of them also had type 2 DM. E-selectin was measured in blood of all patients. In addition, a comprehensive evaluation of the morpho-functional condition of large blood vessels and microvasculature (MV) was performed by laser finger plethysmography (LFP) and nailfold computed videocapillaroscopy (CVC).Results Concentration of E-selectin was increased in IHD patients with type 2 DM (35.2 [29.0; 47.35] ng / ml vs. 31.7 [20.85; 36.68] ng / ml for IHD patients; p=0.028). A significant (p=0.018 and 0.016, respectively) decrease in the phase shift was observed in IHD patients with type 2 DM ( - 4.4 [ - 8.7; - 2.45] ms) compared to IHD patients ( - 1.9 [ - 3.95; - 0.38] ms). The capillary density evaluated in the venous occlusion test was reduced in IHD patients with type 2 DM (67.70 [57.83; 80.69]) compared to IHD patients (80.80 [69.05; 99.08]).Conclusion The signs of ED observed in patients of both groups were more pronounced in IHD patients with type 2 DM.
No takes yet. Share an insight, caveat, or question.
Zhito et al. (2020) conducted a cross-sectional in Ischemic heart disease (n=60). Type 2 diabetes mellitus vs. Ischemic heart disease without type 2 diabetes mellitus was evaluated on Serum E-selectin concentration (ng/ml) (p=0.028). In patients with ischemic heart disease, concomitant type 2 diabetes mellitus was associated with significantly higher serum E-selectin concentrations (35.2 vs 31.7 ng/ml; p=0.028).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: