Key result
Successful resuscitation is linked to a ~53-fold rise in plasma epinephrine after exogenous dosing.
Why the study?
It was uncertain whether plasma epinephrine or norepinephrine concentrations could predict resuscitation outcome after prolonged cardiac arrest and CPR.
Do plasma epinephrine or norepinephrine concentrations predict resuscitation outcome in a canine model of prolonged cardiac arrest?
Comparison
Endogenous catecholamine response vs response to exogenous epinephrine
Design
Preclinical experimental study
Authors
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May mark epinephrine responders in canine resuscitation; leaves open relevance to human cardiac arrest care or interventions.
Do plasma epinephrine or norepinephrine concentrations predict resuscitation outcome in a canine model of prolonged cardiac arrest?
p-value: p=<0.05
Exogenous epinephrine administration during prolonged CPR elicits a catecholamine and coronary perfusion pressure response that correlates with successful resuscitation, despite already elevated endogenous catecholamine levels.
Kern et al. (1989) studied Cardiac arrest (n=9). Intravenous epinephrine (EPI) vs. Unsuccessfully resuscitated animals was evaluated on Resuscitation outcome and catecholamine response (p=<0.05). Successfully resuscitated dogs had a greater increase in plasma epinephrine concentrations after exogenous epinephrine than those not resuscitated (53-fold vs. 23-fold increase, p<0.05).
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